Effect of different salivary glucose concentrations on dual-species biofilms of <i>Candida albicans</i> and <i>Streptococcus mutans</i>

Diabetes mellitus is one of the most prevalent diseases worldwide. The glucose levels found in blood diabetic patients can be reflected saliva, which favor biofilm growth and predispose denture wearers to oral candidiasis. This study aimed evaluate effect different salivary concentrations on dual-species biofilms Candida albicans Streptococcus mutans. A 96-h was developed acrylic resin specimens exposed ‘feast’ (10% sucrose) ‘famine’ periods. Biofilms were constantly equivalent 0, 20, 60 100 mM. Higher resulted increased counts C. a higher quantity insoluble extracellular polysaccharides. All presented high phospholipase activity. characterized by predominance yeast cells microcolonies all groups analyzed with co-localization both species. formed more robust potentially virulent biofilms.